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In vivo Ocular Pharmacokinetics 약물 동태 분석 목록으로
  • 01Rabbit model
  • 02Administration : Topical eye drop, Subconjunctival injection, Intravitreal injection
  • 03Measurement using HPLC, LC/MS/MS
  • 04Pharmacokinetic analysis using for Noncompartmental analysis of Phoenix WinNonlin® software (Certara L.P. LLC.)
약물 동태 분석 정보
Classification Methods
Analysis tissue
  • - Aqueous humor
  • - Vitreous humor
  • - Conjunctiva
  • - Cornea
  • - Retina
  • - Sclera
  • - Blood (serum, plasma)
Method validation
  • - Linearity of Calibration Curve and Quantification Range
  • - Accuracy and Precision
Pharmacokinetics parameters
  • - Cₘₐₓ
  • - Tₘₐₓ
  • - AUC
  • - T½
  • - MRT

  • Pharmacokinetic analysis (Concentration-time graphs)

  • Min & Yang et al. (2019). Preclinical evaluation of UDCA-containing oral formulation in mice for the treatment of wet age-related macular degeneration. Pharmaceutics, 11(11), 561.